U Of M Cancer Genetics Clinic
Med Inn Building
1500 E Medical Center Dr Spc 5830
Floor 3 Reception B
Ann Arbor MI 48109-5830
Telephone: 734-763-2532
Fax: 734-763-7672


  




Cancer Genetics Results Note:

I had the opportunity to speak with the wife of our mutual patient Brian Brookman, by phone on 6/6/2016 to review his genetic test results. Mr. Brookman was originally seen for genetic counseling in the Multidisciplinary Pancreas Clinic due to his personal history of pancreatic cancer diagnosed at age 45, which raised concern for hereditary risk. Genetic testing was ordered, the PancNext panel test through Ambry GeneticLaboratories which includes analysis of the following genes: APC, ATM, BRCA1, BRCA2, CDKN2A, EPCAM, MLH1, MSH2, MSH6, PALB2, PMS2, STK11, and TP53. This testing revealed a pathogenic mutation in the ATM gene (c.3802delG). The remaining genes of this panel were negative with no mutations detected. A copy of his test results accompanies this letter.

ATM gene mutations are inherited in a dominant manner, meaning that all first degree relatives (parents, children and siblings) of a person with an ATM mutation are at 50% risk of inheriting the family mutation. Other relatives are at a risk dependent on their degree of relation.  Now that the family mutation has been identified, predictive genetic testing can be offered to Mr. Brookman’s at risk family members.  If we can be of help in identifying local genetic services for Mr. Brookman's family members, they are encouraged to contact our office. 

Mr. Brookman's wife shared that Mr. Brookman has been set up with hospice services given the advanced state of his disease. She and their daughter are interested in a follow up visit to this clinic to further discuss the implications of this finding later this fall. They will be contacted to set up an appointment. 

I, Jenae Osborne, provided the genetic counseling and communicated the medical recommendations. Ordering physician Dr. Diane Simeone was available for consult.

Please contact our office should you have any questions.  Thank you again for your referral.

Sincerely,

Jenae Osborne, MS, CGC
Certified Genetic Counselor